Who was the first US president who was not born in either Virginia or Massachusetts?

Andrew Jackson is the first US president not to be born in either Virginia or Massachusetts.

https://en.wikipedia.org/wiki/Andrew_Jackson

Here is a list of all US presidents by birthplace:

https://en.wikipedia.org/wiki/List_of_presidents_of_the_United_States_by_home_state

The first six presidents were either born in Virginia (Washington, Jefferson, Madison, Monroe) or Massachusetts (Adams father and son). The 7th president Andrew Jackson was born on March 15, 1767 in the Waxhaw Settlement between in the Carolinas.

At the time of his birth, a border between the Carolinas did not exist. The exact site of his birth is uncertain. Jackson always claimed he was born on the South Carolina side of the new border, however, a midwife reportedly birthed Jackson in a cabin north of the border.