I believe he was referring to the entire plastics industry. Making everything out of plastic was still a relatively new concept. It may also be a reference to "It's a Wonderful Life" when George had the opportunity to get in on the ground floor in the industry producing plane parts out of a lightweight, heavy-duty plastic.
Frustrated by George's lack of response to her affectionate maneuvers, Mary smashes the record that she had put on just for him and demands that he leave. Then the phone rings. It's Sam Wainright, the friend who introduced George to Mary, and he informs her that George's previous tip about plastics has turned out to be excellent advice, but that he's still looking for a place to produce his goods. George advises Sam to consider Bedford Falls' recently closed factory, which, along with its former workforce, could suit his needs. George and Mary share the telephone earpiece as Sam tells George that his father wants to give George a job with generous pay and a prosperous future and that "It's the chance of a lifetime." George, utterly torn between two choices, shouts, "Now, you listen to me! I don't want any plastics, and I don't want any ground floors, and I don't want to get married, ever, to anyone! You understand that? I want to do what I want to do. And you're—and you're—"
At this moment, he realizes he must again make another sacrifice for love, and embraces Mary. At the same time, George also realizes that he must marry his love while at the same time denying himself the prosperous job. After all, the Bailey Building & Loan needs protection from Mr. Potter, and the Bailey Building & Loan needs to protect Bedford Falls from Mr. Potter, too.
https://en.wikipedia.org/wiki/It's_a_Wonderful_Life